Fig 1: Enrichment plot: REACTOME_MITOTIC_M_M_G1_PHASES
Profile of the Running ES Score & Positions of GeneSet Members on the Rank Ordered List
| Dataset | all-ab-ratio-log-sorted |
| Phenotype | NoPhenotypeAvailable |
| Upregulated in class | na_pos |
| GeneSet | REACTOME_MITOTIC_M_M_G1_PHASES |
| Enrichment Score (ES) | 0.5241523 |
| Normalized Enrichment Score (NES) | 2.0209608 |
| Nominal p-value | 0.0 |
| FDR q-value | 9.032131E-4 |
| FWER p-Value | 0.008 |
| PROBE | GENE SYMBOL | GENE_TITLE | RANK IN GENE LIST | RANK METRIC SCORE | RUNNING ES | CORE ENRICHMENT | |
|---|---|---|---|---|---|---|---|
| 1 | PPP2R5D | PPP2R5D Entrez, Source | protein phosphatase 2, regulatory subunit B (B56), delta isoform | 79 | 2.074 | 0.0150 | Yes |
| 2 | MCM4 | MCM4 Entrez, Source | MCM4 minichromosome maintenance deficient 4 (S. cerevisiae) | 89 | 1.993 | 0.0510 | Yes |
| 3 | CKAP5 | CKAP5 Entrez, Source | cytoskeleton associated protein 5 | 93 | 1.977 | 0.0887 | Yes |
| 4 | PRIM2 | 128 | 1.741 | 0.1117 | Yes | ||
| 5 | SPC25 | 141 | 1.669 | 0.1404 | Yes | ||
| 6 | MCM3 | MCM3 Entrez, Source | MCM3 minichromosome maintenance deficient 3 (S. cerevisiae) | 165 | 1.556 | 0.1634 | Yes |
| 7 | PPP2R5C | PPP2R5C Entrez, Source | protein phosphatase 2, regulatory subunit B (B56), gamma isoform | 194 | 1.486 | 0.1834 | Yes |
| 8 | MCM2 | MCM2 Entrez, Source | MCM2 minichromosome maintenance deficient 2, mitotin (S. cerevisiae) | 204 | 1.449 | 0.2088 | Yes |
| 9 | MCM6 | MCM6 Entrez, Source | MCM6 minichromosome maintenance deficient 6 (MIS5 homolog, S. pombe) (S. cerevisiae) | 218 | 1.401 | 0.2319 | Yes |
| 10 | MCM7 | MCM7 Entrez, Source | MCM7 minichromosome maintenance deficient 7 (S. cerevisiae) | 222 | 1.392 | 0.2582 | Yes |
| 11 | PSMD6 | PSMD6 Entrez, Source | proteasome (prosome, macropain) 26S subunit, non-ATPase, 6 | 277 | 1.243 | 0.2650 | Yes |
| 12 | PSMD8 | PSMD8 Entrez, Source | proteasome (prosome, macropain) 26S subunit, non-ATPase, 8 | 311 | 1.176 | 0.2773 | Yes |
| 13 | MCM5 | MCM5 Entrez, Source | MCM5 minichromosome maintenance deficient 5, cell division cycle 46 (S. cerevisiae) | 319 | 1.166 | 0.2979 | Yes |
| 14 | RPS27A | RPS27A Entrez, Source | ribosomal protein S27a | 323 | 1.157 | 0.3195 | Yes |
| 15 | UBA52 | UBA52 Entrez, Source | ubiquitin A-52 residue ribosomal protein fusion product 1 | 324 | 1.157 | 0.3421 | Yes |
| 16 | RANBP2 | RANBP2 Entrez, Source | RAN binding protein 2 | 360 | 1.102 | 0.3523 | Yes |
| 17 | PPP2CA | PPP2CA Entrez, Source | protein phosphatase 2 (formerly 2A), catalytic subunit, alpha isoform | 372 | 1.081 | 0.3699 | Yes |
| 18 | MAPRE1 | MAPRE1 Entrez, Source | microtubule-associated protein, RP/EB family, member 1 | 396 | 1.039 | 0.3828 | Yes |
| 19 | RANGAP1 | RANGAP1 Entrez, Source | Ran GTPase activating protein 1 | 411 | 1.020 | 0.3982 | Yes |
| 20 | RPA2 | RPA2 Entrez, Source | replication protein A2, 32kDa | 430 | 1.005 | 0.4120 | Yes |
| 21 | PSMC3 | PSMC3 Entrez, Source | proteasome (prosome, macropain) 26S subunit, ATPase, 3 | 499 | 0.910 | 0.4078 | Yes |
| 22 | PPP2R1A | PPP2R1A Entrez, Source | protein phosphatase 2 (formerly 2A), regulatory subunit A (PR 65), alpha isoform | 521 | 0.891 | 0.4184 | Yes |
| 23 | PSME1 | PSME1 Entrez, Source | proteasome (prosome, macropain) activator subunit 1 (PA28 alpha) | 566 | 0.848 | 0.4207 | Yes |
| 24 | PSME2 | PSME2 Entrez, Source | proteasome (prosome, macropain) activator subunit 2 (PA28 beta) | 570 | 0.840 | 0.4362 | Yes |
| 25 | PPP2R5A | PPP2R5A Entrez, Source | protein phosphatase 2, regulatory subunit B (B56), alpha isoform | 587 | 0.810 | 0.4468 | Yes |
| 26 | PSME4 | PSME4 Entrez, Source | proteasome (prosome, macropain) activator subunit 4 | 648 | 0.749 | 0.4421 | Yes |
| 27 | PSMB9 | PSMB9 Entrez, Source | proteasome (prosome, macropain) subunit, beta type, 9 (large multifunctional peptidase 2) | 684 | 0.719 | 0.4448 | Yes |
| 28 | SMC3 | SMC3 Entrez, Source | structural maintenance of chromosomes 3 | 685 | 0.718 | 0.4588 | Yes |
| 29 | XPO1 | XPO1 Entrez, Source | exportin 1 (CRM1 homolog, yeast) | 724 | 0.685 | 0.4599 | Yes |
| 30 | CLIP1 | 726 | 0.684 | 0.4730 | Yes | ||
| 31 | PSMD5 | PSMD5 Entrez, Source | proteasome (prosome, macropain) 26S subunit, non-ATPase, 5 | 749 | 0.665 | 0.4789 | Yes |
| 32 | PSMC2 | PSMC2 Entrez, Source | proteasome (prosome, macropain) 26S subunit, ATPase, 2 | 770 | 0.649 | 0.4851 | Yes |
| 33 | RPS27 | RPS27 Entrez, Source | ribosomal protein S27 (metallopanstimulin 1) | 792 | 0.630 | 0.4906 | Yes |
| 34 | PSMB7 | PSMB7 Entrez, Source | proteasome (prosome, macropain) subunit, beta type, 7 | 797 | 0.622 | 0.5015 | Yes |
| 35 | PSMD2 | PSMD2 Entrez, Source | proteasome (prosome, macropain) 26S subunit, non-ATPase, 2 | 798 | 0.622 | 0.5136 | Yes |
| 36 | PSMD9 | PSMD9 Entrez, Source | proteasome (prosome, macropain) 26S subunit, non-ATPase, 9 | 852 | 0.577 | 0.5077 | Yes |
| 37 | PSMD14 | PSMD14 Entrez, Source | proteasome (prosome, macropain) 26S subunit, non-ATPase, 14 | 861 | 0.564 | 0.5162 | Yes |
| 38 | PSMB1 | PSMB1 Entrez, Source | proteasome (prosome, macropain) subunit, beta type, 1 | 871 | 0.557 | 0.5242 | Yes |
| 39 | PSMA2 | PSMA2 Entrez, Source | proteasome (prosome, macropain) subunit, alpha type, 2 | 940 | 0.504 | 0.5120 | No |
| 40 | PSMB10 | PSMB10 Entrez, Source | proteasome (prosome, macropain) subunit, beta type, 10 | 960 | 0.493 | 0.5155 | No |
| 41 | PSMC1 | PSMC1 Entrez, Source | proteasome (prosome, macropain) 26S subunit, ATPase, 1 | 966 | 0.490 | 0.5235 | No |
| 42 | PSMB8 | PSMB8 Entrez, Source | proteasome (prosome, macropain) subunit, beta type, 8 (large multifunctional peptidase 7) | 1081 | 0.406 | 0.4945 | No |
| 43 | RCC2 | RCC2 Entrez, Source | regulator of chromosome condensation 2 | 1099 | 0.388 | 0.4966 | No |
| 44 | PSMC5 | PSMC5 Entrez, Source | proteasome (prosome, macropain) 26S subunit, ATPase, 5 | 1124 | 0.371 | 0.4961 | No |
| 45 | SEC13 | 1132 | 0.364 | 0.5010 | No | ||
| 46 | PSMD3 | PSMD3 Entrez, Source | proteasome (prosome, macropain) 26S subunit, non-ATPase, 3 | 1262 | 0.281 | 0.4647 | No |
| 47 | PSMC6 | PSMC6 Entrez, Source | proteasome (prosome, macropain) 26S subunit, ATPase, 6 | 1298 | 0.254 | 0.4584 | No |
| 48 | RPA1 | RPA1 Entrez, Source | replication protein A1, 70kDa | 1299 | 0.253 | 0.4633 | No |
| 49 | PRIM1 | PRIM1 Entrez, Source | primase, polypeptide 1, 49kDa | 1309 | 0.247 | 0.4652 | No |
| 50 | PSMB2 | PSMB2 Entrez, Source | proteasome (prosome, macropain) subunit, beta type, 2 | 1343 | 0.227 | 0.4590 | No |
| 51 | PSMD7 | PSMD7 Entrez, Source | proteasome (prosome, macropain) 26S subunit, non-ATPase, 7 (Mov34 homolog) | 1362 | 0.215 | 0.4574 | No |
| 52 | PSMA4 | PSMA4 Entrez, Source | proteasome (prosome, macropain) subunit, alpha type, 4 | 1441 | 0.159 | 0.4353 | No |
| 53 | PSMA1 | PSMA1 Entrez, Source | proteasome (prosome, macropain) subunit, alpha type, 1 | 1476 | 0.140 | 0.4270 | No |
| 54 | NUDC | NUDC Entrez, Source | nuclear distribution gene C homolog (A. nidulans) | 1480 | 0.136 | 0.4287 | No |
| 55 | PSMB3 | PSMB3 Entrez, Source | proteasome (prosome, macropain) subunit, beta type, 3 | 1481 | 0.134 | 0.4313 | No |
| 56 | PSMD12 | PSMD12 Entrez, Source | proteasome (prosome, macropain) 26S subunit, non-ATPase, 12 | 1490 | 0.128 | 0.4312 | No |
| 57 | PSMA3 | PSMA3 Entrez, Source | proteasome (prosome, macropain) subunit, alpha type, 3 | 1562 | 0.081 | 0.4099 | No |
| 58 | PSMD11 | PSMD11 Entrez, Source | proteasome (prosome, macropain) 26S subunit, non-ATPase, 11 | 1585 | 0.069 | 0.4041 | No |
| 59 | PSMA6 | PSMA6 Entrez, Source | proteasome (prosome, macropain) subunit, alpha type, 6 | 1600 | 0.057 | 0.4007 | No |
| 60 | PSMD13 | PSMD13 Entrez, Source | proteasome (prosome, macropain) 26S subunit, non-ATPase, 13 | 1641 | 0.041 | 0.3885 | No |
| 61 | CDK2 | CDK2 Entrez, Source | cyclin-dependent kinase 2 | 1659 | 0.029 | 0.3836 | No |
| 62 | PSMA7 | PSMA7 Entrez, Source | proteasome (prosome, macropain) subunit, alpha type, 7 | 1675 | 0.020 | 0.3791 | No |
| 63 | PSMB4 | PSMB4 Entrez, Source | proteasome (prosome, macropain) subunit, beta type, 4 | 1713 | -0.002 | 0.3672 | No |
| 64 | POLA1 | POLA1 Entrez, Source | polymerase (DNA directed), alpha 1 | 1726 | -0.009 | 0.3635 | No |
| 65 | PSMC4 | PSMC4 Entrez, Source | proteasome (prosome, macropain) 26S subunit, ATPase, 4 | 1732 | -0.011 | 0.3621 | No |
| 66 | PSMF1 | PSMF1 Entrez, Source | proteasome (prosome, macropain) inhibitor subunit 1 (PI31) | 1755 | -0.023 | 0.3554 | No |
| 67 | PSMB6 | PSMB6 Entrez, Source | proteasome (prosome, macropain) subunit, beta type, 6 | 1868 | -0.099 | 0.3212 | No |
| 68 | KNTC1 | KNTC1 Entrez, Source | kinetochore associated 1 | 1880 | -0.104 | 0.3197 | No |
| 69 | PSMA5 | PSMA5 Entrez, Source | proteasome (prosome, macropain) subunit, alpha type, 5 | 1900 | -0.115 | 0.3158 | No |
| 70 | PSMD1 | PSMD1 Entrez, Source | proteasome (prosome, macropain) 26S subunit, non-ATPase, 1 | 1957 | -0.151 | 0.3006 | No |
| 71 | NUP85 | NUP85 Entrez, Source | nucleoporin 85kDa | 1976 | -0.164 | 0.2980 | No |
| 72 | PSMD10 | PSMD10 Entrez, Source | proteasome (prosome, macropain) 26S subunit, non-ATPase, 10 | 2041 | -0.202 | 0.2812 | No |
| 73 | SEH1L | SEH1L Entrez, Source | SEH1-like (S. cerevisiae) | 2171 | -0.281 | 0.2450 | No |
| 74 | PSMD4 | PSMD4 Entrez, Source | proteasome (prosome, macropain) 26S subunit, non-ATPase, 4 | 2230 | -0.329 | 0.2327 | No |
| 75 | ZW10 | ZW10 Entrez, Source | ZW10, kinetochore associated, homolog (Drosophila) | 2237 | -0.339 | 0.2374 | No |
| 76 | PSMB5 | PSMB5 Entrez, Source | proteasome (prosome, macropain) subunit, beta type, 5 | 2284 | -0.372 | 0.2298 | No |
| 77 | RPA3 | RPA3 Entrez, Source | replication protein A3, 14kDa | 2295 | -0.378 | 0.2339 | No |
| 78 | PAFAH1B1 | PAFAH1B1 Entrez, Source | platelet-activating factor acetylhydrolase, isoform Ib, alpha subunit 45kDa | 2346 | -0.427 | 0.2261 | No |
| 79 | NUP43 | NUP43 Entrez, Source | nucleoporin 43kDa | 2396 | -0.467 | 0.2194 | No |
| 80 | SMC1A | SMC1A Entrez, Source | structural maintenance of chromosomes 1A | 3080 | -1.595 | 0.0297 | No |
