Profile of the Running ES Score & Positions of GeneSet Members on the Rank Ordered List
| Dataset | all-ab-ratio-log-sorted |
| Phenotype | NoPhenotypeAvailable |
| Upregulated in class | na_neg |
| GeneSet | REACTOME_SRP_DEPENDENT_COTRANSLATIONAL_PROTEIN_TARGETING_TO_MEMBRANE |
| Enrichment Score (ES) | -0.46297556 |
| Normalized Enrichment Score (NES) | -2.044727 |
| Nominal p-value | 0.0 |
| FDR q-value | 9.689588E-4 |
| FWER p-Value | 0.017 |
| PROBE | GENE SYMBOL | GENE_TITLE | RANK IN GENE LIST | RANK METRIC SCORE | RUNNING ES | CORE ENRICHMENT | |
|---|---|---|---|---|---|---|---|
| 1 | RPN1 | RPN1 Entrez, Source | ribophorin I | 262 | 1.276 | -0.0614 | No |
| 2 | RPS27A | RPS27A Entrez, Source | ribosomal protein S27a | 323 | 1.157 | -0.0595 | No |
| 3 | UBA52 | UBA52 Entrez, Source | ubiquitin A-52 residue ribosomal protein fusion product 1 | 324 | 1.157 | -0.0380 | No |
| 4 | RPS15 | RPS15 Entrez, Source | ribosomal protein S15 | 446 | 0.977 | -0.0592 | No |
| 5 | SRP9 | SRP9 Entrez, Source | signal recognition particle 9kDa | 516 | 0.898 | -0.0649 | No |
| 6 | SEC61B | SEC61B Entrez, Source | Sec61 beta subunit | 595 | 0.801 | -0.0754 | No |
| 7 | RPS28 | RPS28 Entrez, Source | ribosomal protein S28 | 687 | 0.717 | -0.0917 | No |
| 8 | RPS27 | RPS27 Entrez, Source | ribosomal protein S27 (metallopanstimulin 1) | 792 | 0.630 | -0.1138 | No |
| 9 | TRAM1 | TRAM1 Entrez, Source | translocation associated membrane protein 1 | 912 | 0.523 | -0.1427 | No |
| 10 | SEC61G | SEC61G Entrez, Source | Sec61 gamma subunit | 1144 | 0.358 | -0.2111 | No |
| 11 | SPCS3 | SPCS3 Entrez, Source | signal peptidase complex subunit 3 homolog (S. cerevisiae) | 1240 | 0.297 | -0.2365 | No |
| 12 | SRPR | SRPR Entrez, Source | signal recognition particle receptor ('docking protein') | 1291 | 0.259 | -0.2479 | No |
| 13 | RPL12 | RPL12 Entrez, Source | ribosomal protein L12 | 1337 | 0.232 | -0.2582 | No |
| 14 | RPL7A | RPL7A Entrez, Source | ribosomal protein L7a | 1360 | 0.217 | -0.2613 | No |
| 15 | RPL15 | RPL15 Entrez, Source | ribosomal protein L15 | 1392 | 0.196 | -0.2678 | No |
| 16 | SRPRB | SRPRB Entrez, Source | signal recognition particle receptor, B subunit | 1431 | 0.165 | -0.2770 | No |
| 17 | RPL32 | RPL32 Entrez, Source | ribosomal protein L32 | 1442 | 0.156 | -0.2774 | No |
| 18 | RPL28 | RPL28 Entrez, Source | ribosomal protein L28 | 1455 | 0.150 | -0.2785 | No |
| 19 | SRP14 | SRP14 Entrez, Source | signal recognition particle 14kDa (homologous Alu RNA binding protein) | 1504 | 0.120 | -0.2919 | No |
| 20 | RPS2 | RPS2 Entrez, Source | ribosomal protein S2 | 1554 | 0.085 | -0.3062 | No |
| 21 | SEC11A | 1715 | -0.002 | -0.3582 | No | ||
| 22 | RPL29 | RPL29 Entrez, Source | ribosomal protein L29 | 1783 | -0.039 | -0.3792 | No |
| 23 | RPL27A | RPL27A Entrez, Source | ribosomal protein L27a | 1824 | -0.066 | -0.3910 | No |
| 24 | RPS13 | RPS13 Entrez, Source | ribosomal protein S13 | 1836 | -0.072 | -0.3932 | No |
| 25 | RPL21 | RPL21 Entrez, Source | ribosomal protein L21 | 1842 | -0.075 | -0.3934 | No |
| 26 | SSR4 | SSR4 Entrez, Source | signal sequence receptor, delta (translocon-associated protein delta) | 1850 | -0.080 | -0.3942 | No |
| 27 | FAU | FAU Entrez, Source | Finkel-Biskis-Reilly murine sarcoma virus (FBR-MuSV) ubiquitously expressed (fox derived); ribosomal protein S30 | 1873 | -0.101 | -0.3995 | No |
| 28 | RPS29 | RPS29 Entrez, Source | ribosomal protein S29 | 1916 | -0.123 | -0.4108 | No |
| 29 | RPL10A | RPL10A Entrez, Source | ribosomal protein L10a | 1941 | -0.141 | -0.4160 | No |
| 30 | RPL11 | RPL11 Entrez, Source | ribosomal protein L11 | 1984 | -0.171 | -0.4265 | No |
| 31 | RPS5 | RPS5 Entrez, Source | ribosomal protein S5 | 2048 | -0.206 | -0.4431 | No |
| 32 | RPS14 | RPS14 Entrez, Source | ribosomal protein S14 | 2056 | -0.216 | -0.4414 | No |
| 33 | RPS8 | RPS8 Entrez, Source | ribosomal protein S8 | 2062 | -0.220 | -0.4389 | No |
| 34 | RPL39 | RPL39 Entrez, Source | ribosomal protein L39 | 2137 | -0.260 | -0.4582 | Yes |
| 35 | RPL4 | RPL4 Entrez, Source | ribosomal protein L4 | 2143 | -0.262 | -0.4549 | Yes |
| 36 | RPL6 | RPL6 Entrez, Source | ribosomal protein L6 | 2152 | -0.269 | -0.4525 | Yes |
| 37 | RPS20 | RPS20 Entrez, Source | ribosomal protein S20 | 2181 | -0.288 | -0.4563 | Yes |
| 38 | RPS9 | RPS9 Entrez, Source | ribosomal protein S9 | 2188 | -0.294 | -0.4528 | Yes |
| 39 | RPS16 | RPS16 Entrez, Source | ribosomal protein S16 | 2194 | -0.297 | -0.4489 | Yes |
| 40 | RPS19 | RPS19 Entrez, Source | ribosomal protein S19 | 2199 | -0.302 | -0.4446 | Yes |
| 41 | SSR3 | SSR3 Entrez, Source | signal sequence receptor, gamma (translocon-associated protein gamma) | 2217 | -0.317 | -0.4442 | Yes |
| 42 | SPCS2 | SPCS2 Entrez, Source | signal peptidase complex subunit 2 homolog (S. cerevisiae) | 2221 | -0.319 | -0.4393 | Yes |
| 43 | RPS6 | RPS6 Entrez, Source | ribosomal protein S6 | 2223 | -0.320 | -0.4337 | Yes |
| 44 | RPS7 | RPS7 Entrez, Source | ribosomal protein S7 | 2225 | -0.326 | -0.4280 | Yes |
| 45 | RPS3A | RPS3A Entrez, Source | ribosomal protein S3A | 2245 | -0.343 | -0.4278 | Yes |
| 46 | RPL18 | RPL18 Entrez, Source | ribosomal protein L18 | 2291 | -0.376 | -0.4354 | Yes |
| 47 | RPL27 | RPL27 Entrez, Source | ribosomal protein L27 | 2315 | -0.403 | -0.4354 | Yes |
| 48 | RPS3 | RPS3 Entrez, Source | ribosomal protein S3 | 2324 | -0.410 | -0.4304 | Yes |
| 49 | RPS18 | RPS18 Entrez, Source | ribosomal protein S18 | 2327 | -0.414 | -0.4234 | Yes |
| 50 | RPS21 | RPS21 Entrez, Source | ribosomal protein S21 | 2331 | -0.416 | -0.4167 | Yes |
| 51 | RPL13A | RPL13A Entrez, Source | ribosomal protein L13a | 2350 | -0.432 | -0.4145 | Yes |
| 52 | RPS25 | RPS25 Entrez, Source | ribosomal protein S25 | 2379 | -0.451 | -0.4152 | Yes |
| 53 | RPN2 | RPN2 Entrez, Source | ribophorin II | 2393 | -0.465 | -0.4108 | Yes |
| 54 | SSR1 | SSR1 Entrez, Source | signal sequence receptor, alpha (translocon-associated protein alpha) | 2403 | -0.475 | -0.4049 | Yes |
| 55 | RPL8 | RPL8 Entrez, Source | ribosomal protein L8 | 2406 | -0.477 | -0.3967 | Yes |
| 56 | RPS24 | RPS24 Entrez, Source | ribosomal protein S24 | 2468 | -0.526 | -0.4068 | Yes |
| 57 | RPL13 | RPL13 Entrez, Source | ribosomal protein L13 | 2477 | -0.536 | -0.3995 | Yes |
| 58 | RPS26 | RPS26 Entrez, Source | ribosomal protein S26 | 2508 | -0.564 | -0.3987 | Yes |
| 59 | RPS15A | RPS15A Entrez, Source | ribosomal protein S15a | 2529 | -0.588 | -0.3943 | Yes |
| 60 | RPL18A | RPL18A Entrez, Source | ribosomal protein L18a | 2544 | -0.601 | -0.3877 | Yes |
| 61 | RPS12 | RPS12 Entrez, Source | ribosomal protein S12 | 2545 | -0.602 | -0.3766 | Yes |
| 62 | RPL24 | RPL24 Entrez, Source | ribosomal protein L24 | 2568 | -0.627 | -0.3721 | Yes |
| 63 | RPL17 | RPL17 Entrez, Source | ribosomal protein L17 | 2581 | -0.638 | -0.3641 | Yes |
| 64 | RPL5 | RPL5 Entrez, Source | ribosomal protein L5 | 2587 | -0.643 | -0.3538 | Yes |
| 65 | RPL14 | RPL14 Entrez, Source | ribosomal protein L14 | 2593 | -0.647 | -0.3434 | Yes |
| 66 | RPS4X | RPS4X Entrez, Source | ribosomal protein S4, X-linked | 2610 | -0.670 | -0.3362 | Yes |
| 67 | RPL23A | RPL23A Entrez, Source | ribosomal protein L23a | 2618 | -0.683 | -0.3258 | Yes |
| 68 | RPL37A | RPL37A Entrez, Source | ribosomal protein L37a | 2640 | -0.711 | -0.3195 | Yes |
| 69 | RPL7 | RPL7 Entrez, Source | ribosomal protein L7 | 2649 | -0.722 | -0.3087 | Yes |
| 70 | RPSA | RPSA Entrez, Source | ribosomal protein SA | 2659 | -0.732 | -0.2980 | Yes |
| 71 | RPL19 | RPL19 Entrez, Source | ribosomal protein L19 | 2665 | -0.735 | -0.2860 | Yes |
| 72 | RPL34 | RPL34 Entrez, Source | ribosomal protein L34 | 2667 | -0.739 | -0.2726 | Yes |
| 73 | RPL30 | RPL30 Entrez, Source | ribosomal protein L30 | 2669 | -0.742 | -0.2592 | Yes |
| 74 | RPL10 | RPL10 Entrez, Source | ribosomal protein L10 | 2701 | -0.776 | -0.2549 | Yes |
| 75 | RPL31 | RPL31 Entrez, Source | ribosomal protein L31 | 2718 | -0.794 | -0.2454 | Yes |
| 76 | RPLP2 | RPLP2 Entrez, Source | ribosomal protein, large, P2 | 2727 | -0.803 | -0.2331 | Yes |
| 77 | RPL35 | RPL35 Entrez, Source | ribosomal protein L35 | 2733 | -0.811 | -0.2196 | Yes |
| 78 | RPL3 | RPL3 Entrez, Source | ribosomal protein L3 | 2740 | -0.822 | -0.2064 | Yes |
| 79 | RPL36 | RPL36 Entrez, Source | ribosomal protein L36 | 2752 | -0.838 | -0.1944 | Yes |
| 80 | RPS10 | RPS10 Entrez, Source | ribosomal protein S10 | 2762 | -0.859 | -0.1814 | Yes |
| 81 | RPL35A | RPL35A Entrez, Source | ribosomal protein L35a | 2783 | -0.885 | -0.1715 | Yes |
| 82 | RPS11 | RPS11 Entrez, Source | ribosomal protein S11 | 2803 | -0.914 | -0.1607 | Yes |
| 83 | RPL38 | RPL38 Entrez, Source | ribosomal protein L38 | 2804 | -0.916 | -0.1437 | Yes |
| 84 | RPLP1 | RPLP1 Entrez, Source | ribosomal protein, large, P1 | 2806 | -0.919 | -0.1270 | Yes |
| 85 | SRP54 | SRP54 Entrez, Source | signal recognition particle 54kDa | 2818 | -0.935 | -0.1132 | Yes |
| 86 | DDOST | DDOST Entrez, Source | dolichyl-diphosphooligosaccharide-protein glycosyltransferase | 2822 | -0.942 | -0.0967 | Yes |
| 87 | RPL9 | RPL9 Entrez, Source | ribosomal protein L9 | 2848 | -0.979 | -0.0867 | Yes |
| 88 | RPS23 | RPS23 Entrez, Source | ribosomal protein S23 | 2894 | -1.046 | -0.0819 | Yes |
| 89 | SRP68 | SRP68 Entrez, Source | signal recognition particle 68kDa | 2917 | -1.094 | -0.0688 | Yes |
| 90 | SRP72 | SRP72 Entrez, Source | signal recognition particle 72kDa | 2988 | -1.242 | -0.0685 | Yes |
| 91 | RPL22 | RPL22 Entrez, Source | ribosomal protein L22 | 3020 | -1.357 | -0.0534 | Yes |
| 92 | RPS17 | RPS17 Entrez, Source | ribosomal protein S17 | 3048 | -1.454 | -0.0352 | Yes |
| 93 | SRP19 | SRP19 Entrez, Source | signal recognition particle 19kDa | 3127 | -1.902 | -0.0252 | Yes |
| 94 | RPL23 | RPL23 Entrez, Source | ribosomal protein L23 | 3149 | -2.132 | 0.0075 | Yes |
