Profile of the Running ES Score & Positions of GeneSet Members on the Rank Ordered List
| Dataset | all-ab-ratio-log-sorted |
| Phenotype | NoPhenotypeAvailable |
| Upregulated in class | na_pos |
| GeneSet | REACTOME_CELL_CYCLE_MITOTIC |
| Enrichment Score (ES) | 0.5464444 |
| Normalized Enrichment Score (NES) | 2.222154 |
| Nominal p-value | 0.0 |
| FDR q-value | 0.0 |
| FWER p-Value | 0.0 |
| PROBE | GENE SYMBOL | GENE_TITLE | RANK IN GENE LIST | RANK METRIC SCORE | RUNNING ES | CORE ENRICHMENT | |
|---|---|---|---|---|---|---|---|
| 1 | PPP2R5D | PPP2R5D Entrez, Source | protein phosphatase 2, regulatory subunit B (B56), delta isoform | 79 | 2.074 | -0.0020 | Yes |
| 2 | MCM4 | MCM4 Entrez, Source | MCM4 minichromosome maintenance deficient 4 (S. cerevisiae) | 89 | 1.993 | 0.0180 | Yes |
| 3 | CKAP5 | CKAP5 Entrez, Source | cytoskeleton associated protein 5 | 93 | 1.977 | 0.0398 | Yes |
| 4 | CDK1 | 99 | 1.906 | 0.0601 | Yes | ||
| 5 | CDKN2A | CDKN2A Entrez, Source | cyclin-dependent kinase inhibitor 2A (melanoma, p16, inhibits CDK4) | 121 | 1.768 | 0.0736 | Yes |
| 6 | GINS1 | GINS1 Entrez, Source | GINS complex subunit 1 (Psf1 homolog) | 125 | 1.751 | 0.0928 | Yes |
| 7 | PRIM2 | 128 | 1.741 | 0.1122 | Yes | ||
| 8 | SPC25 | 141 | 1.669 | 0.1275 | Yes | ||
| 9 | UBE2E1 | UBE2E1 Entrez, Source | ubiquitin-conjugating enzyme E2E 1 (UBC4/5 homolog, yeast) | 152 | 1.597 | 0.1426 | Yes |
| 10 | MCM3 | MCM3 Entrez, Source | MCM3 minichromosome maintenance deficient 3 (S. cerevisiae) | 165 | 1.556 | 0.1566 | Yes |
| 11 | TYMS | TYMS Entrez, Source | thymidylate synthetase | 172 | 1.542 | 0.1724 | Yes |
| 12 | CDK4 | CDK4 Entrez, Source | cyclin-dependent kinase 4 | 191 | 1.490 | 0.1837 | Yes |
| 13 | PPP2R5C | PPP2R5C Entrez, Source | protein phosphatase 2, regulatory subunit B (B56), gamma isoform | 194 | 1.486 | 0.2002 | Yes |
| 14 | MCM2 | MCM2 Entrez, Source | MCM2 minichromosome maintenance deficient 2, mitotin (S. cerevisiae) | 204 | 1.449 | 0.2139 | Yes |
| 15 | PRKACA | PRKACA Entrez, Source | protein kinase, cAMP-dependent, catalytic, alpha | 208 | 1.426 | 0.2294 | Yes |
| 16 | MCM6 | MCM6 Entrez, Source | MCM6 minichromosome maintenance deficient 6 (MIS5 homolog, S. pombe) (S. cerevisiae) | 218 | 1.401 | 0.2425 | Yes |
| 17 | UBE2C | UBE2C Entrez, Source | ubiquitin-conjugating enzyme E2C | 219 | 1.398 | 0.2587 | Yes |
| 18 | MCM7 | MCM7 Entrez, Source | MCM7 minichromosome maintenance deficient 7 (S. cerevisiae) | 222 | 1.392 | 0.2740 | Yes |
| 19 | PCNA | PCNA Entrez, Source | proliferating cell nuclear antigen | 240 | 1.326 | 0.2837 | Yes |
| 20 | PSMD6 | PSMD6 Entrez, Source | proteasome (prosome, macropain) 26S subunit, non-ATPase, 6 | 277 | 1.243 | 0.2863 | Yes |
| 21 | PSMD8 | PSMD8 Entrez, Source | proteasome (prosome, macropain) 26S subunit, non-ATPase, 8 | 311 | 1.176 | 0.2890 | Yes |
| 22 | MCM5 | MCM5 Entrez, Source | MCM5 minichromosome maintenance deficient 5, cell division cycle 46 (S. cerevisiae) | 319 | 1.166 | 0.3001 | Yes |
| 23 | RPS27A | RPS27A Entrez, Source | ribosomal protein S27a | 323 | 1.157 | 0.3125 | Yes |
| 24 | UBA52 | UBA52 Entrez, Source | ubiquitin A-52 residue ribosomal protein fusion product 1 | 324 | 1.157 | 0.3258 | Yes |
| 25 | RRM2 | RRM2 Entrez, Source | ribonucleotide reductase M2 polypeptide | 346 | 1.129 | 0.3320 | Yes |
| 26 | RANBP2 | RANBP2 Entrez, Source | RAN binding protein 2 | 360 | 1.102 | 0.3404 | Yes |
| 27 | PPP2CA | PPP2CA Entrez, Source | protein phosphatase 2 (formerly 2A), catalytic subunit, alpha isoform | 372 | 1.081 | 0.3492 | Yes |
| 28 | MAPRE1 | MAPRE1 Entrez, Source | microtubule-associated protein, RP/EB family, member 1 | 396 | 1.039 | 0.3537 | Yes |
| 29 | RANGAP1 | RANGAP1 Entrez, Source | Ran GTPase activating protein 1 | 411 | 1.020 | 0.3608 | Yes |
| 30 | RPA2 | RPA2 Entrez, Source | replication protein A2, 32kDa | 430 | 1.005 | 0.3665 | Yes |
| 31 | FEN1 | FEN1 Entrez, Source | flap structure-specific endonuclease 1 | 448 | 0.974 | 0.3722 | Yes |
| 32 | TUBGCP2 | TUBGCP2 Entrez, Source | tubulin, gamma complex associated protein 2 | 458 | 0.964 | 0.3803 | Yes |
| 33 | TUBB | TUBB Entrez, Source | tubulin, beta | 473 | 0.947 | 0.3866 | Yes |
| 34 | HSP90AA1 | HSP90AA1 Entrez, Source | heat shock protein 90kDa alpha (cytosolic), class A member 1 | 477 | 0.944 | 0.3965 | Yes |
| 35 | SKP1 | 484 | 0.935 | 0.4053 | Yes | ||
| 36 | PSMC3 | PSMC3 Entrez, Source | proteasome (prosome, macropain) 26S subunit, ATPase, 3 | 499 | 0.910 | 0.4112 | Yes |
| 37 | RFC2 | RFC2 Entrez, Source | replication factor C (activator 1) 2, 40kDa | 511 | 0.903 | 0.4180 | Yes |
| 38 | PPP2R1A | PPP2R1A Entrez, Source | protein phosphatase 2 (formerly 2A), regulatory subunit A (PR 65), alpha isoform | 521 | 0.891 | 0.4253 | Yes |
| 39 | TUBB4A | 531 | 0.881 | 0.4325 | Yes | ||
| 40 | TUBB4B | 545 | 0.867 | 0.4383 | Yes | ||
| 41 | PSME1 | PSME1 Entrez, Source | proteasome (prosome, macropain) activator subunit 1 (PA28 alpha) | 566 | 0.848 | 0.4415 | Yes |
| 42 | PSME2 | PSME2 Entrez, Source | proteasome (prosome, macropain) activator subunit 2 (PA28 beta) | 570 | 0.840 | 0.4502 | Yes |
| 43 | PPP2R5A | PPP2R5A Entrez, Source | protein phosphatase 2, regulatory subunit B (B56), alpha isoform | 587 | 0.810 | 0.4543 | Yes |
| 44 | CETN2 | CETN2 Entrez, Source | centrin, EF-hand protein, 2 | 606 | 0.787 | 0.4574 | Yes |
| 45 | POLD1 | POLD1 Entrez, Source | polymerase (DNA directed), delta 1, catalytic subunit 125kDa | 608 | 0.784 | 0.4661 | Yes |
| 46 | GINS4 | GINS4 Entrez, Source | GINS complex subunit 4 (Sld5 homolog) | 612 | 0.780 | 0.4741 | Yes |
| 47 | RFC4 | RFC4 Entrez, Source | replication factor C (activator 1) 4, 37kDa | 631 | 0.765 | 0.4770 | Yes |
| 48 | PSME4 | PSME4 Entrez, Source | proteasome (prosome, macropain) activator subunit 4 | 648 | 0.749 | 0.4804 | Yes |
| 49 | PRKAR2B | PRKAR2B Entrez, Source | protein kinase, cAMP-dependent, regulatory, type II, beta | 654 | 0.744 | 0.4874 | Yes |
| 50 | TUBA1A | 680 | 0.722 | 0.4875 | Yes | ||
| 51 | PSMB9 | PSMB9 Entrez, Source | proteasome (prosome, macropain) subunit, beta type, 9 (large multifunctional peptidase 2) | 684 | 0.719 | 0.4948 | Yes |
| 52 | SMC3 | SMC3 Entrez, Source | structural maintenance of chromosomes 3 | 685 | 0.718 | 0.5030 | Yes |
| 53 | XPO1 | XPO1 Entrez, Source | exportin 1 (CRM1 homolog, yeast) | 724 | 0.685 | 0.4985 | Yes |
| 54 | CLIP1 | 726 | 0.684 | 0.5060 | Yes | ||
| 55 | POLD2 | POLD2 Entrez, Source | polymerase (DNA directed), delta 2, regulatory subunit 50kDa | 742 | 0.670 | 0.5088 | Yes |
| 56 | PSMD5 | PSMD5 Entrez, Source | proteasome (prosome, macropain) 26S subunit, non-ATPase, 5 | 749 | 0.665 | 0.5145 | Yes |
| 57 | PSMC2 | PSMC2 Entrez, Source | proteasome (prosome, macropain) 26S subunit, ATPase, 2 | 770 | 0.649 | 0.5155 | Yes |
| 58 | RPS27 | RPS27 Entrez, Source | ribosomal protein S27 (metallopanstimulin 1) | 792 | 0.630 | 0.5158 | Yes |
| 59 | PSMB7 | PSMB7 Entrez, Source | proteasome (prosome, macropain) subunit, beta type, 7 | 797 | 0.622 | 0.5217 | Yes |
| 60 | PSMD2 | PSMD2 Entrez, Source | proteasome (prosome, macropain) 26S subunit, non-ATPase, 2 | 798 | 0.622 | 0.5289 | Yes |
| 61 | YWHAG | YWHAG Entrez, Source | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma polypeptide | 828 | 0.599 | 0.5262 | Yes |
| 62 | PSMD9 | PSMD9 Entrez, Source | proteasome (prosome, macropain) 26S subunit, non-ATPase, 9 | 852 | 0.577 | 0.5253 | Yes |
| 63 | TUBG1 | TUBG1 Entrez, Source | tubulin, gamma 1 | 858 | 0.568 | 0.5303 | Yes |
| 64 | TUBG2 | TUBG2 Entrez, Source | tubulin, gamma 2 | 859 | 0.568 | 0.5368 | Yes |
| 65 | PSMD14 | PSMD14 Entrez, Source | proteasome (prosome, macropain) 26S subunit, non-ATPase, 14 | 861 | 0.564 | 0.5430 | Yes |
| 66 | PSMB1 | PSMB1 Entrez, Source | proteasome (prosome, macropain) subunit, beta type, 1 | 871 | 0.557 | 0.5464 | Yes |
| 67 | DYNC1I2 | DYNC1I2 Entrez, Source | dynein, cytoplasmic 1, intermediate chain 2 | 909 | 0.528 | 0.5404 | No |
| 68 | CUL1 | CUL1 Entrez, Source | cullin 1 | 927 | 0.515 | 0.5407 | No |
| 69 | PSMA2 | PSMA2 Entrez, Source | proteasome (prosome, macropain) subunit, alpha type, 2 | 940 | 0.504 | 0.5426 | No |
| 70 | PSMB10 | PSMB10 Entrez, Source | proteasome (prosome, macropain) subunit, beta type, 10 | 960 | 0.493 | 0.5421 | No |
| 71 | PSMC1 | PSMC1 Entrez, Source | proteasome (prosome, macropain) 26S subunit, ATPase, 1 | 966 | 0.490 | 0.5461 | No |
| 72 | AKAP9 | AKAP9 Entrez, Source | A kinase (PRKA) anchor protein (yotiao) 9 | 1061 | 0.426 | 0.5201 | No |
| 73 | PSMB8 | PSMB8 Entrez, Source | proteasome (prosome, macropain) subunit, beta type, 8 (large multifunctional peptidase 7) | 1081 | 0.406 | 0.5186 | No |
| 74 | RCC2 | RCC2 Entrez, Source | regulator of chromosome condensation 2 | 1099 | 0.388 | 0.5175 | No |
| 75 | PSMC5 | PSMC5 Entrez, Source | proteasome (prosome, macropain) 26S subunit, ATPase, 5 | 1124 | 0.371 | 0.5139 | No |
| 76 | SEC13 | 1132 | 0.364 | 0.5158 | No | ||
| 77 | NUMA1 | NUMA1 Entrez, Source | nuclear mitotic apparatus protein 1 | 1145 | 0.357 | 0.5160 | No |
| 78 | DCTN1 | DCTN1 Entrez, Source | dynactin 1 (p150, glued homolog, Drosophila) | 1153 | 0.351 | 0.5177 | No |
| 79 | DYNLL1 | DYNLL1 Entrez, Source | dynein, light chain, LC8-type 1 | 1185 | 0.334 | 0.5114 | No |
| 80 | LIG1 | LIG1 Entrez, Source | ligase I, DNA, ATP-dependent | 1223 | 0.307 | 0.5028 | No |
| 81 | DCTN2 | DCTN2 Entrez, Source | dynactin 2 (p50) | 1231 | 0.301 | 0.5040 | No |
| 82 | PSMD3 | PSMD3 Entrez, Source | proteasome (prosome, macropain) 26S subunit, non-ATPase, 3 | 1262 | 0.281 | 0.4974 | No |
| 83 | YWHAE | YWHAE Entrez, Source | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon polypeptide | 1268 | 0.276 | 0.4989 | No |
| 84 | PSMC6 | PSMC6 Entrez, Source | proteasome (prosome, macropain) 26S subunit, ATPase, 6 | 1298 | 0.254 | 0.4923 | No |
| 85 | RPA1 | RPA1 Entrez, Source | replication protein A1, 70kDa | 1299 | 0.253 | 0.4952 | No |
| 86 | PRIM1 | PRIM1 Entrez, Source | primase, polypeptide 1, 49kDa | 1309 | 0.247 | 0.4951 | No |
| 87 | PSMB2 | PSMB2 Entrez, Source | proteasome (prosome, macropain) subunit, beta type, 2 | 1343 | 0.227 | 0.4869 | No |
| 88 | ACTR1A | ACTR1A Entrez, Source | ARP1 actin-related protein 1 homolog A, centractin alpha (yeast) | 1350 | 0.221 | 0.4875 | No |
| 89 | PSMD7 | PSMD7 Entrez, Source | proteasome (prosome, macropain) 26S subunit, non-ATPase, 7 (Mov34 homolog) | 1362 | 0.215 | 0.4864 | No |
| 90 | PSMA4 | PSMA4 Entrez, Source | proteasome (prosome, macropain) subunit, alpha type, 4 | 1441 | 0.159 | 0.4626 | No |
| 91 | RBBP4 | RBBP4 Entrez, Source | retinoblastoma binding protein 4 | 1469 | 0.145 | 0.4554 | No |
| 92 | PSMA1 | PSMA1 Entrez, Source | proteasome (prosome, macropain) subunit, alpha type, 1 | 1476 | 0.140 | 0.4551 | No |
| 93 | NUDC | NUDC Entrez, Source | nuclear distribution gene C homolog (A. nidulans) | 1480 | 0.136 | 0.4557 | No |
| 94 | PSMB3 | PSMB3 Entrez, Source | proteasome (prosome, macropain) subunit, beta type, 3 | 1481 | 0.134 | 0.4572 | No |
| 95 | PSMD12 | PSMD12 Entrez, Source | proteasome (prosome, macropain) 26S subunit, non-ATPase, 12 | 1490 | 0.128 | 0.4560 | No |
| 96 | DCTN3 | DCTN3 Entrez, Source | dynactin 3 (p22) | 1506 | 0.117 | 0.4525 | No |
| 97 | PSMA3 | PSMA3 Entrez, Source | proteasome (prosome, macropain) subunit, alpha type, 3 | 1562 | 0.081 | 0.4354 | No |
| 98 | PSMD11 | PSMD11 Entrez, Source | proteasome (prosome, macropain) 26S subunit, non-ATPase, 11 | 1585 | 0.069 | 0.4290 | No |
| 99 | PSMA6 | PSMA6 Entrez, Source | proteasome (prosome, macropain) subunit, alpha type, 6 | 1600 | 0.057 | 0.4250 | No |
| 100 | PSMD13 | PSMD13 Entrez, Source | proteasome (prosome, macropain) 26S subunit, non-ATPase, 13 | 1641 | 0.041 | 0.4124 | No |
| 101 | CDK2 | CDK2 Entrez, Source | cyclin-dependent kinase 2 | 1659 | 0.029 | 0.4071 | No |
| 102 | PSMA7 | PSMA7 Entrez, Source | proteasome (prosome, macropain) subunit, alpha type, 7 | 1675 | 0.020 | 0.4024 | No |
| 103 | PSMB4 | PSMB4 Entrez, Source | proteasome (prosome, macropain) subunit, beta type, 4 | 1713 | -0.002 | 0.3903 | No |
| 104 | POLA1 | POLA1 Entrez, Source | polymerase (DNA directed), alpha 1 | 1726 | -0.009 | 0.3865 | No |
| 105 | PSMC4 | PSMC4 Entrez, Source | proteasome (prosome, macropain) 26S subunit, ATPase, 4 | 1732 | -0.011 | 0.3850 | No |
| 106 | PSMF1 | PSMF1 Entrez, Source | proteasome (prosome, macropain) inhibitor subunit 1 (PI31) | 1755 | -0.023 | 0.3780 | No |
| 107 | DYNC1H1 | DYNC1H1 Entrez, Source | dynein, cytoplasmic 1, heavy chain 1 | 1761 | -0.025 | 0.3767 | No |
| 108 | PSMB6 | PSMB6 Entrez, Source | proteasome (prosome, macropain) subunit, beta type, 6 | 1868 | -0.099 | 0.3431 | No |
| 109 | KNTC1 | KNTC1 Entrez, Source | kinetochore associated 1 | 1880 | -0.104 | 0.3406 | No |
| 110 | PSMA5 | PSMA5 Entrez, Source | proteasome (prosome, macropain) subunit, alpha type, 5 | 1900 | -0.115 | 0.3357 | No |
| 111 | PSMD1 | PSMD1 Entrez, Source | proteasome (prosome, macropain) 26S subunit, non-ATPase, 1 | 1957 | -0.151 | 0.3191 | No |
| 112 | NUP85 | NUP85 Entrez, Source | nucleoporin 85kDa | 1976 | -0.164 | 0.3151 | No |
| 113 | PSMD10 | PSMD10 Entrez, Source | proteasome (prosome, macropain) 26S subunit, non-ATPase, 10 | 2041 | -0.202 | 0.2964 | No |
| 114 | SEH1L | SEH1L Entrez, Source | SEH1-like (S. cerevisiae) | 2171 | -0.281 | 0.2574 | No |
| 115 | CDK7 | CDK7 Entrez, Source | cyclin-dependent kinase 7 (MO15 homolog, Xenopus laevis, cdk-activating kinase) | 2214 | -0.314 | 0.2472 | No |
| 116 | PSMD4 | PSMD4 Entrez, Source | proteasome (prosome, macropain) 26S subunit, non-ATPase, 4 | 2230 | -0.329 | 0.2461 | No |
| 117 | ZW10 | ZW10 Entrez, Source | ZW10, kinetochore associated, homolog (Drosophila) | 2237 | -0.339 | 0.2480 | No |
| 118 | CDC16 | CDC16 Entrez, Source | CDC16 cell division cycle 16 homolog (S. cerevisiae) | 2254 | -0.354 | 0.2468 | No |
| 119 | PSMB5 | PSMB5 Entrez, Source | proteasome (prosome, macropain) subunit, beta type, 5 | 2284 | -0.372 | 0.2416 | No |
| 120 | RPA3 | RPA3 Entrez, Source | replication protein A3, 14kDa | 2295 | -0.378 | 0.2427 | No |
| 121 | PAFAH1B1 | PAFAH1B1 Entrez, Source | platelet-activating factor acetylhydrolase, isoform Ib, alpha subunit 45kDa | 2346 | -0.427 | 0.2312 | No |
| 122 | NUP43 | NUP43 Entrez, Source | nucleoporin 43kDa | 2396 | -0.467 | 0.2205 | No |
| 123 | TUBGCP3 | TUBGCP3 Entrez, Source | tubulin, gamma complex associated protein 3 | 3007 | -1.297 | 0.0354 | No |
| 124 | SMC1A | SMC1A Entrez, Source | structural maintenance of chromosomes 1A | 3080 | -1.595 | 0.0302 | No |
