Dataset | all-ab-ratio-log-sorted |
Phenotype | NoPhenotypeAvailable |
Upregulated in class | na_pos |
GeneSet | REACTOME_CELL_CYCLE_CHECKPOINTS |
Enrichment Score (ES) | 0.5709196 |
Normalized Enrichment Score (NES) | 2.0613515 |
Nominal p-value | 0.0 |
FDR q-value | 7.167495E-4 |
FWER p-Value | 0.005 |
PROBE | GENE SYMBOL | GENE_TITLE | RANK IN GENE LIST | RANK METRIC SCORE | RUNNING ES | CORE ENRICHMENT | |
---|---|---|---|---|---|---|---|
1 | TP53 | TP53 Entrez,  Source | tumor protein p53 (Li-Fraumeni syndrome) | 76 | 2.086 | 0.0304 | Yes |
2 | MCM4 | MCM4 Entrez,  Source | MCM4 minichromosome maintenance deficient 4 (S. cerevisiae) | 89 | 1.993 | 0.0789 | Yes |
3 | CDK1 | 99 | 1.906 | 0.1261 | Yes | ||
4 | UBE2E1 | UBE2E1 Entrez,  Source | ubiquitin-conjugating enzyme E2E 1 (UBC4/5 homolog, yeast) | 152 | 1.597 | 0.1514 | Yes |
5 | MCM3 | MCM3 Entrez,  Source | MCM3 minichromosome maintenance deficient 3 (S. cerevisiae) | 165 | 1.556 | 0.1884 | Yes |
6 | MCM2 | MCM2 Entrez,  Source | MCM2 minichromosome maintenance deficient 2, mitotin (S. cerevisiae) | 204 | 1.449 | 0.2142 | Yes |
7 | MCM6 | MCM6 Entrez,  Source | MCM6 minichromosome maintenance deficient 6 (MIS5 homolog, S. pombe) (S. cerevisiae) | 218 | 1.401 | 0.2469 | Yes |
8 | UBE2C | UBE2C Entrez,  Source | ubiquitin-conjugating enzyme E2C | 219 | 1.398 | 0.2836 | Yes |
9 | MCM7 | MCM7 Entrez,  Source | MCM7 minichromosome maintenance deficient 7 (S. cerevisiae) | 222 | 1.392 | 0.3196 | Yes |
10 | PSMD6 | PSMD6 Entrez,  Source | proteasome (prosome, macropain) 26S subunit, non-ATPase, 6 | 277 | 1.243 | 0.3349 | Yes |
11 | PSMD8 | PSMD8 Entrez,  Source | proteasome (prosome, macropain) 26S subunit, non-ATPase, 8 | 311 | 1.176 | 0.3552 | Yes |
12 | MCM5 | MCM5 Entrez,  Source | MCM5 minichromosome maintenance deficient 5, cell division cycle 46 (S. cerevisiae) | 319 | 1.166 | 0.3836 | Yes |
13 | RPS27A | RPS27A Entrez,  Source | ribosomal protein S27a | 323 | 1.157 | 0.4130 | Yes |
14 | UBA52 | UBA52 Entrez,  Source | ubiquitin A-52 residue ribosomal protein fusion product 1 | 324 | 1.157 | 0.4434 | Yes |
15 | RPA2 | RPA2 Entrez,  Source | replication protein A2, 32kDa | 430 | 1.005 | 0.4361 | Yes |
16 | PSMC3 | PSMC3 Entrez,  Source | proteasome (prosome, macropain) 26S subunit, ATPase, 3 | 499 | 0.910 | 0.4382 | Yes |
17 | RFC2 | RFC2 Entrez,  Source | replication factor C (activator 1) 2, 40kDa | 511 | 0.903 | 0.4583 | Yes |
18 | PSME1 | PSME1 Entrez,  Source | proteasome (prosome, macropain) activator subunit 1 (PA28 alpha) | 566 | 0.848 | 0.4633 | Yes |
19 | PSME2 | PSME2 Entrez,  Source | proteasome (prosome, macropain) activator subunit 2 (PA28 beta) | 570 | 0.840 | 0.4844 | Yes |
20 | RFC4 | RFC4 Entrez,  Source | replication factor C (activator 1) 4, 37kDa | 631 | 0.765 | 0.4852 | Yes |
21 | PSME4 | PSME4 Entrez,  Source | proteasome (prosome, macropain) activator subunit 4 | 648 | 0.749 | 0.4998 | Yes |
22 | PSMB9 | PSMB9 Entrez,  Source | proteasome (prosome, macropain) subunit, beta type, 9 (large multifunctional peptidase 2) | 684 | 0.719 | 0.5074 | Yes |
23 | PSMD5 | PSMD5 Entrez,  Source | proteasome (prosome, macropain) 26S subunit, non-ATPase, 5 | 749 | 0.665 | 0.5043 | Yes |
24 | PSMC2 | PSMC2 Entrez,  Source | proteasome (prosome, macropain) 26S subunit, ATPase, 2 | 770 | 0.649 | 0.5149 | Yes |
25 | PSMB7 | PSMB7 Entrez,  Source | proteasome (prosome, macropain) subunit, beta type, 7 | 797 | 0.622 | 0.5229 | Yes |
26 | PSMD2 | PSMD2 Entrez,  Source | proteasome (prosome, macropain) 26S subunit, non-ATPase, 2 | 798 | 0.622 | 0.5393 | Yes |
27 | PSMD9 | PSMD9 Entrez,  Source | proteasome (prosome, macropain) 26S subunit, non-ATPase, 9 | 852 | 0.577 | 0.5374 | Yes |
28 | PSMD14 | PSMD14 Entrez,  Source | proteasome (prosome, macropain) 26S subunit, non-ATPase, 14 | 861 | 0.564 | 0.5497 | Yes |
29 | PSMB1 | PSMB1 Entrez,  Source | proteasome (prosome, macropain) subunit, beta type, 1 | 871 | 0.557 | 0.5614 | Yes |
30 | PSMA2 | PSMA2 Entrez,  Source | proteasome (prosome, macropain) subunit, alpha type, 2 | 940 | 0.504 | 0.5528 | Yes |
31 | PSMB10 | PSMB10 Entrez,  Source | proteasome (prosome, macropain) subunit, beta type, 10 | 960 | 0.493 | 0.5597 | Yes |
32 | PSMC1 | PSMC1 Entrez,  Source | proteasome (prosome, macropain) 26S subunit, ATPase, 1 | 966 | 0.490 | 0.5709 | Yes |
33 | PSMB8 | PSMB8 Entrez,  Source | proteasome (prosome, macropain) subunit, beta type, 8 (large multifunctional peptidase 7) | 1081 | 0.406 | 0.5450 | No |
34 | PSMC5 | PSMC5 Entrez,  Source | proteasome (prosome, macropain) 26S subunit, ATPase, 5 | 1124 | 0.371 | 0.5412 | No |
35 | PSMD3 | PSMD3 Entrez,  Source | proteasome (prosome, macropain) 26S subunit, non-ATPase, 3 | 1262 | 0.281 | 0.5046 | No |
36 | PSMC6 | PSMC6 Entrez,  Source | proteasome (prosome, macropain) 26S subunit, ATPase, 6 | 1298 | 0.254 | 0.5000 | No |
37 | RPA1 | RPA1 Entrez,  Source | replication protein A1, 70kDa | 1299 | 0.253 | 0.5066 | No |
38 | PSMB2 | PSMB2 Entrez,  Source | proteasome (prosome, macropain) subunit, beta type, 2 | 1343 | 0.227 | 0.4988 | No |
39 | PSMD7 | PSMD7 Entrez,  Source | proteasome (prosome, macropain) 26S subunit, non-ATPase, 7 (Mov34 homolog) | 1362 | 0.215 | 0.4987 | No |
40 | PSMA4 | PSMA4 Entrez,  Source | proteasome (prosome, macropain) subunit, alpha type, 4 | 1441 | 0.159 | 0.4778 | No |
41 | PSMA1 | PSMA1 Entrez,  Source | proteasome (prosome, macropain) subunit, alpha type, 1 | 1476 | 0.140 | 0.4705 | No |
42 | PSMB3 | PSMB3 Entrez,  Source | proteasome (prosome, macropain) subunit, beta type, 3 | 1481 | 0.134 | 0.4728 | No |
43 | PSMD12 | PSMD12 Entrez,  Source | proteasome (prosome, macropain) 26S subunit, non-ATPase, 12 | 1490 | 0.128 | 0.4736 | No |
44 | PSMA3 | PSMA3 Entrez,  Source | proteasome (prosome, macropain) subunit, alpha type, 3 | 1562 | 0.081 | 0.4529 | No |
45 | PSMD11 | PSMD11 Entrez,  Source | proteasome (prosome, macropain) 26S subunit, non-ATPase, 11 | 1585 | 0.069 | 0.4476 | No |
46 | PSMA6 | PSMA6 Entrez,  Source | proteasome (prosome, macropain) subunit, alpha type, 6 | 1600 | 0.057 | 0.4446 | No |
47 | PSMD13 | PSMD13 Entrez,  Source | proteasome (prosome, macropain) 26S subunit, non-ATPase, 13 | 1641 | 0.041 | 0.4328 | No |
48 | CDK2 | CDK2 Entrez,  Source | cyclin-dependent kinase 2 | 1659 | 0.029 | 0.4281 | No |
49 | PSMA7 | PSMA7 Entrez,  Source | proteasome (prosome, macropain) subunit, alpha type, 7 | 1675 | 0.020 | 0.4238 | No |
50 | PSMB4 | PSMB4 Entrez,  Source | proteasome (prosome, macropain) subunit, beta type, 4 | 1713 | -0.002 | 0.4120 | No |
51 | PSMC4 | PSMC4 Entrez,  Source | proteasome (prosome, macropain) 26S subunit, ATPase, 4 | 1732 | -0.011 | 0.4065 | No |
52 | PSMF1 | PSMF1 Entrez,  Source | proteasome (prosome, macropain) inhibitor subunit 1 (PI31) | 1755 | -0.023 | 0.4001 | No |
53 | PSMB6 | PSMB6 Entrez,  Source | proteasome (prosome, macropain) subunit, beta type, 6 | 1868 | -0.099 | 0.3667 | No |
54 | PSMA5 | PSMA5 Entrez,  Source | proteasome (prosome, macropain) subunit, alpha type, 5 | 1900 | -0.115 | 0.3598 | No |
55 | PSMD1 | PSMD1 Entrez,  Source | proteasome (prosome, macropain) 26S subunit, non-ATPase, 1 | 1957 | -0.151 | 0.3457 | No |
56 | PSMD10 | PSMD10 Entrez,  Source | proteasome (prosome, macropain) 26S subunit, non-ATPase, 10 | 2041 | -0.202 | 0.3244 | No |
57 | PSMD4 | PSMD4 Entrez,  Source | proteasome (prosome, macropain) 26S subunit, non-ATPase, 4 | 2230 | -0.329 | 0.2726 | No |
58 | CDC16 | CDC16 Entrez,  Source | CDC16 cell division cycle 16 homolog (S. cerevisiae) | 2254 | -0.354 | 0.2745 | No |
59 | PSMB5 | PSMB5 Entrez,  Source | proteasome (prosome, macropain) subunit, beta type, 5 | 2284 | -0.372 | 0.2750 | No |
60 | RPA3 | RPA3 Entrez,  Source | replication protein A3, 14kDa | 2295 | -0.378 | 0.2817 | No |